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Brennan reunites with her brother, whom Booth brings to Washington, D. The businessman's body is found in a car on the train tracks, and at first glance, it is an apparent suicide.
While investigating a possible connection between the two victims, Brennan and her team discover the businessman is still alive, but severely injured, at a local hospital, and the body at the scene is someone else.
As the clues begin to unravel, the investigation gets more complicated when details of the man's private life are revealed, leading Brennan and Booth to a private detective who may hold key information. Camille Saroyan, a first-rate pathologist who has been hired as the head of forensics at the Jeffersonian, and more importantly, Brennan's boss.
It doesn't take long for Brennan to figure out "Cam" is a little too familiar with Booth and that they share something of a past.
Two cases are brought to the Jeffersonian Institute; one concerning the human remains of whom the FBI thinks is mob boss James Cuguni, while the other concerns a possible murder victim of serial killer Kevin Hollings.
When Brennan narrowly misses being the target of a shooting while waiting for a date, it becomes probable that the shooter is connected to one of these cases.
The team helps FBI Deputy Director Sam Cullen's daughter, Amy, when she contracts a rare form of lung cancer after receiving a bone graft.
Booth and Brennan learn she is not the only victim with this rare form of cancer.
Brennan's parents when her mother's remains are discovered. Brennan and Booth investigate the site of a train wreck where the bodies of a senator and a high-profile businessman are found within the wreckage.
A decomposed corpse in a superhero outfit is found in an alley.
Booth and Brennan discover that the victim was a fan of comic books and had engaged in role playing with his friends, but his attempt at being a hero had deadly consequences.
Brennan joins Booth in his investigation regarding a dug-up corpse found in the back of a gang member's car.
When Brennan and her team examine the original burial site of the corpse, they find another empty grave, leading Booth to believe that there was a double homicide.
Brennan's former professor and ex-lover, Michael, comes to Washington, D. As Brennan works to gather evidence for the prosecution, she discovers that Michael has been appointed as an expert witness for the defence.