Sedating ssris

Posted by / 01-May-2020 18:21

Sedating ssris

Treatment should be discontinued in any patient who develops seizures, or where there is an increase in seizure frequency – hepatic impairment: Following a single 15 mg oral dose of mirtazapine, the clearance of mirtazapine was approximately 35 % decreased in mild to moderate hepatically impaired patients, compared to subjects with normal hepatic function.

The average plasma concentration of mirtazapine was about 55 % increased.

It is general clinical experience that the risk of suicide may increase in the early stages of recovery.

Patients with a history of suicide-related events or those exhibiting a significant degree of suicidal ideation prior to commencement of treatment are known to be at greater risk of suicidal thoughts or suicide attempts, and should receive careful monitoring during treatment.

The tablets should be taken orally, with fluid, and swallowed without chewing.

Mirtazapine should not be used in the treatment of children and adolescents under the age of 18 years.

The physician should be alert for symptoms like fever, sore throat, stomatitis or other signs of infection; when such symptoms occur, treatment should be stopped and blood counts taken.

Symptoms of serotonin syndrome may be hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital signs, mental status changes that include confusion, irritability and extreme agitation progressing to delirium and coma.Suicide-related behaviours (suicide attempt and suicidal thoughts), and hostility (predominantly aggression, oppositional behaviour and anger) were more frequently observed in clinical trials among children and adolescents treated with antidepressants compared to those treated with placebo.If, based on clinical need, a decision to treat is nevertheless taken, the patient should be carefully monitored for the appearance of suicidal symptoms.This should be taken into account when prescribing Mirtazapine to this category of patients, particularly with severe hepatic impairment, as patients with severe hepatic impairment have not been investigated (see section 4.4).Mirtazapine has an elimination half-life of 20-40 hours and therefore Mirtazapine is suitable for once daily administration.

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In elderly patients an increase in dosing should be done under close supervision to elicit a satisfactory and safe response.

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